Brief Literature Review on the Mechanisms Involved in Producing Axial Difussion Injury
Keywords:brain injuries, diffuse axonal injury, axotomy, beta-amyloid,
AbstractCurrent work reviews the concept, pathological mechanism and the process of diagnosing diffuse axonal lesions (DAI). The pathological mechanism underlying DAI is complicated, including axotomy with the appearance of retraction bulbs, interrupted protein transport along axonal neurophilaments, massive influx of calcium ions and calpain-mediated hydrolysis, axonal cytoskeletal cell degradation, beta-amyloid precursor protein accumulation and changes in glial cells. The transition from primary axotomy to secondary axotomy causes a very complex, calciumdependent biochemical cascade.
How to Cite
Hunea, I., Damian, S. I., David, S., Diac, M. M., Bulgaru Iliescu, D., & Ciocoiu, M. (2017). Brief Literature Review on the Mechanisms Involved in Producing Axial Difussion Injury. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 8(4), pp. 91-98. Retrieved from https://lumenpublishing.com/journals/index.php/brain/article/view/2105
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant this journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work, with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as an earlier and greater citation of published work (See The Effect of Open Access).
BRAIN. Broad Research in Artificial Intelligence and Neuroscience Journal has an Attribution-NonCommercial-NoDerivs