Brief Literature Review on the Mechanisms Involved in Producing Axial Difussion Injury
Keywords:
brain injuries, diffuse axonal injury, axotomy, beta-amyloid,Abstract
Current work reviews the concept, pathological mechanism and the process of diagnosing diffuse axonal lesions (DAI). The pathological mechanism underlying DAI is complicated, including axotomy with the appearance of retraction bulbs, interrupted protein transport along axonal neurophilaments, massive influx of calcium ions and calpain-mediated hydrolysis, axonal cytoskeletal cell degradation, beta-amyloid precursor protein accumulation and changes in glial cells. The transition from primary axotomy to secondary axotomy causes a very complex, calciumdependent biochemical cascade.
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Published
2017-12-23
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Hunea, I., Damian, S. I., David, S., Diac, M. M., Bulgaru Iliescu, D., & Ciocoiu, M. (2017). Brief Literature Review on the Mechanisms Involved in Producing Axial Difussion Injury. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 8(4), pp. 91-98. Retrieved from https://lumenpublishing.com/journals/index.php/brain/article/view/2105
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