Effects of Endurance Workouts on Thyroid Hormone Metabolism and Biochemical Markers in Athletes
DOI:
https://doi.org/10.18662/brain/11.3/114Keywords:
Exercise Thyroid hormones, biochemistry, sportsmanAbstract
Objective: Exercises can create differences in the organism by affecting the hormonal system and hemostasis. Evaluation of hormonal changes along with physical activity, many factors such as physical and physiological state of athletes, environmental factors and nutritional status are effective and affect the performance. In this study, as a result of endurance workouts, chronic changes in athletes' thyroid hormone metabolism and biochemical markers were evaluated. Method: 16 male athletes formed the research group. The athletes participating in the study received endurance training for 60 minutes a day, three days a week for 12 weeks. Blood samples were taken from the athletes before the session and after the session. The levels of Thyroid hormones, iron, iron binding capacity, UIBC, erythrocyte, leukocyte and platelet were determined in blood samples. Data were considered by using SPSS statistical package software. Findings: A significant difference was observed in athletes' thyroid hormone values as a result of the training sessions: Thyroid Stimulating Hormone (TSH), Thyroxine (T4) and Triiodothyronine (T3) levels were detected to be statistically different in pre-post test (p <0,05). As a result of the applied workouts changes were observed in the erythrocyte, leukocyte and platelet values of the athletes, and a significant difference was seen in general (p <0,05). Results: Applied regular and long-term endurance training created differences in athletes' thyroid hormone metabolism and biochemical markers. It is thought that these findings will positively affect the fight against the stress experienced by athletes during their competitions and increase their performance.
References
Akbulut, T., Cinar, V., & Erdogan, R. (2019). The Effect of High Intensity Interval Training Applied with Vitamin E Reinforcement on Thyroid Hormone Metabolism. Revista Romaneasca pentru Educatie Multidimensionala, 11(4Sup1), 01-07. https://doi.org/10.18662/rrem/173
Badenhorst, C. E., Dawson, B., Cox, G. R., Laarakkers, C. M., Swinkels, D. W., & Peeling, P. (2015). Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses. European Journal of Applied Physiology, 115(10), 2215-2222. https://doi.org/10.1007/s00421-015-3202-0
Burden, R. J., Pollock, N., Whyte, G. P., Richards, T., Moore, B., Busbridge, M., Srai, s. K., Otto, J., & Pedlar, C. R. (2014). Effect of intravenous iron on aerobic capacity and iron metabolism in elite athletes. Medicine & Science in Sports & Exercise, 47(7), 1399-1407. https://doi.org/10.1249/MSS.0000000000000568
Cheserek, M. J., Wu, G., Li, L., Li, L., Karangwa, E., Shi, Y., & Le, G. (2016). Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. The Journal of Nutritional Biochemistry, 33, 36-44. https://doi.org/10.1016/j.jnutbio.2016.02.008
Chi, H. C., Chen, C. Y., Tsai, M. M., Tsai, C. Y., & Lin, K. H. (2013). Molecular functions of thyroid hormones and their clinical significance in liver-related diseases. BioMed Research International, 16, 1-16, 601361. https://doi.org/10.1155/2013/601361
Chicharro, J. L., Hoyos, J., Bandrés, F., Terrados, N., Fernández, B., & Lucía, A. (2001). Thyroid hormone levels during a 3-week professional road cycling competition. Hormone Research in Paediatrics, 56(5-6), 159-164. https://doi.org/10.1159/000048112
Chifman, J., Laubenbacher, R., & Torti, S. V. (2014). A systems biology approach to iron metabolism. In J. C., Seth, K. Marek, N. L. Joshua (Eds.), A Systems Biology Approach to Blood (pp. 201-225). Springer.
Cinar, V., Akbulut, T., & Sarikaya, M. (2017). Effect of zinc supplement and weight lifting exercise on thyroid hormone levels. Indian Journal of Physiology and Pharmacology, 61(3), 232-236. https://www.ijpp.com/IJPP%20archives/2017_61_3/232-236.pdf
Corrales-Agudelo, V., Parra-Sosa, B. E., & Burgos-Herrera, L. C. (2016). Proteínas relacionadas con el metabolismo del hierro corporal. Perspectivas en Nutrición Humana, 18(1), 95-116. http://dx.doi.org/10.17533/udea.penh.v18n1a0
Corsetti, R., Lombardi, G., Lanteri, P., Colombini, A., Graziani, R., & Banfi, G. (2012). Haematological and iron metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race. Clinical Chemistry and Laboratory Medicine, 50(5), 949-956. http://dx.doi.org/10.1515/cclm-2011-0857
Denis, R. S., & Conway, J. L. (2019). Iron deficiency and aerobic endurance performance in a female club runner. Science & Sports, 34(1), 45-51. https://doi.org/10.1016/j.scispo.2018.04.012
Dillmann, W. (2010). Cardiac hypertrophy and thyroid hormone signaling. Heart failure reviews, 15(2), 125-132. https://doi.org/10.1007/s10741-008-9125-7
Elliott-Sale, K. J., Tenforde, A. S., Parziale, A. L., Holtzman, B., & Ackerman, K. E. (2018). Endocrine effects of relative energy deficiency in sport. International Journal of Sport Nutrition and Exercise Metabolism, 28(4), 335-349. https://doi.org/10.1123/ijsnem.2018-0127
Friedenreich, C. M., Neilson, H. K., O’Reilly, R., Duha, A., Yasui, Y., Morielli, A. R., Adams, S. C., & Courneya, K. S. (2015). Effects of a high vs moderate volume of aerobic exercise on adiposity outcomes in postmenopausal women: a randomized clinical trial. JAMA Oncology, 1(6), 766-776. https://doi.org/10.1001/jamaoncol.2015.2239
Gallego-Narbón, A., Zapatera, B., & Vaquero, M. P. (2019). Physiological and Dietary Determinants of Iron Status in Spanish Vegetarians. Nutrients, 11(8), 1734. https://doi.org/10.3390/nu11081734
Govus, A. D., Garvican-Lewis, L. A., Abbiss, C. R., Peeling, P., & Gore, C. J. (2015). Pre-altitude serum ferritin levels and daily oral iron supplement dose mediate iron parameter and hemoglobin mass responses to altitude exposure. PLoS One, 10(8), e0135120. https://doi.org/10.1371/journal.pone.0135120
Hinton, P. S. (2014). Iron and the endurance athlete. Applied Physiology, Nutrition, and Metabolism, 39(9), 1012-1018. https://doi.org/10.1139/apnm-2014-0147
Johannsen, D. L., Galgani, J. E., Johannsen, N. M., Zhang, Z., Covington, J. D., & Ravussin, E. (2012). Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans. PLoS One, 7(7), e40837. https://doi.org/10.1371/journal.pone.0040837
Louzada, R. A., & Carvalho, D. P. (2018). Similarities and differences in the peripheral actions of thyroid hormones and their metabolites. Frontiers in endocrinology, 9, 394. https://doi.org/10.3389/fendo.2018.00394
Masaki, M., Koide, K., Goda, A., Miyazaki, A., Masuyama, T., & Koshiba, M. (2019). Effect of acute aerobic exercise on arterial stiffness and thyroid-stimulating hormone in subclinical hypothyroidism. Heart and vessels, 34, 1309–1316. https://doi.org/10.1007/s00380-019-01355-8
Maske, U. A., & Barnwal, S. L. (2016). Effect of yogic practices on the level of thyroxine (T4) in the female patients of hyperthyroidism. International Journal of Medical and Health Research, 2(8), 69-72. http://www.medicalsciencejournal.com/archives/2016/vol2/issue8/2-8-45
Mielgo-Ayuso, J., Zourdos, M. C., Calleja-González, J., Urdampilleta, A., & Ostojic, S. (2015). Iron supplementation prevents a decline in iron stores and enhances strength performance in elite female volleyball players during the competitive season. Applied Physiology, Nutrition, and Metabolism, 40(6), 615-622. https://doi.org/10.1139/apnm-2014-0500
Mullur, R., Liu, Y. Y., & Brent, G. A. (2014). Thyroid hormone regulation of metabolism. Physiological reviews, 94(2), 355-382. https://doi.org/10.1152/physrev.00030.2013
Mwafy, S., Yassin, M., & Mousa, R. (2018). Thyroid hormones, lipid profile and anthropometric changes after programmed weight loss in Palestinian obese adult females. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(3), 269-273. https://doi.org/10.1016/j.dsx.2017.12.009
Nandadeva, T. D. P., Dissanayake, A. M. S. D. M., Rajaratne, A. A. J., & Nanayakkara, S. D. I. (2019). Effect of iron supplementation during high altitude training on haemoglobin and iron status of Sri Lankan middle-and long-distance athletes. Sri Lanka Journal of Medicine, 28(1), 29-40. http://doi.org/10.4038/sljm.v28i1.114
Pantopoulos, K., Porwal, S. K., Tartakoff, A., & Devireddy, L. (2012). Mechanisms of mammalian iron homeostasis. Biochemistry, 51(29), 5705-5724. http://doi.org/10.1021/bi300752r
Pascual, A., & Aranda, A. (2013). Thyroid hormone receptors, cell growth and differentiation. Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(7), 3908-3916. http://doi.org/10.1016/j.bbagen.2012.03.012
Peeling, P., Sim, M., Badenhorst, C. E., Dawson, B., Govus, A. D., Abbiss, C. R., Swinkels, D. W., & Trinder, D. (2014). Iron status and the acute post-exercise hepcidin response in athletes. PloS one, 9(3), e93002. https://doi.org/10.1371/journal.pone.0093002
Philippou, A., Maridaki, M., Tenta, R., & Koutsilieris, M. (2017). Hormonal responses following eccentric exercise in humans. Hormones, 16(4), 405-413. https://doi.org/10.14310/horm.2002.1761
Refaat, B., Abdelghany, A. H., BaSalamah, M. A., El-Boshy, M., Ahmad, J., & Idris, S. (2018). Acute and chronic iron overloading differentially modulates the expression of cellular iron-homeostatic molecules in normal rat kidney. Journal of Histochemistry & Cytochemistry, 66(11), 825-839. https://doi.org/10.1369/0022155418782696
Sim, M., Dawson, B., Landers, G. J., Swinkels, D. W., Tjalsma, H., Wiegerinck, E. T., ... & Peeling, P. (2014). A seven day running training period increases basal urinary hepcidin levels as compared to cycling. Journal of the International Society of Sports Nutrition, 11(1), 14. https://doi.org/10.1186/1550-2783-11-14
Skarpańska-Stejnborn, A., Basta, P., Trzeciak, J., & Szcześniak-Pilaczyńska, Ł. (2015). Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes. European Journal of Applied Physiology, 115(2), 345-351. https://doi.org/10.1007/s00421-014-3018-3
Song, Y., Yao, X., & Ying, H. (2011). Thyroid hormone action in metabolic regulation. Protein & cell, 2(5), 358–368. https://doi.org/10.1007/s13238-011-1046-x
Soria, M., Anson, M., & Escanero, J. F. (2016). Correlation analysis of exercise-induced changes in plasma trace element and hormone levels during incremental exercise in well-trained athletes. Biological Trace Element Research, 170(1), 55-64. https://doi.org/10.1007/s12011-015-0466-5
Sultan, S., & Rashed, L. (2009). Effect of Low Calorie Diet and Exercise on Thyroid Hormones and Leptin Levels. Medical Journal of Cairo University,77(1),33-39. https://www.medicaljournalofcairouniversity.net/images/pdf/2009/march/06.pdf
Tayebi, S. M., Mahmoudi, A. A., Shirazi, E., & Sangi, M. (2017). Acute response of some iron indices of young elite wrestlers to three types of aerobic, anaerobic, and wrestling exercise. Montenegrin Journal of Sports Science and Medicine, 6(1), 5. http://www.mjssm.me/clanci/MJSSM_March_2017_Tayebi.pdf
Teixeira, R. B., Zimmer, A., de Castro, A. L., de Lima-Seolin, B. G., Türck, P., Siqueira, R., Belló-Kleina, A., Singal. P. K., Sander, A. & da Rosa Araujo, A. S. (2017). Long-term T3 and T4 treatment as an alternative to aerobic exercise training in improving cardiac function post-myocardial infarction. Biomedicine & Pharmacotherapy, 95, 965-973. https://doi.org/10.1016/j.biopha.2017.09.021
Vincent, J. B., Neggers, Y., & McClung, J. (2019). Roles of Chromium (III), Vanadium, Iron, and Zinc in Sports Nutrition. In D. Bagchi, S. Nair, & C. K. Sen (Eds.), Nutrition and Enhanced Sports Performance (Second Edition) Muscle Building, Endurance, and Strength (pp. 653-664). Academic Press.
Yehuda-Shnaidman, E., Kalderon, B., & Bar-Tana, J. (2013). Thyroid hormone, thyromimetics, and metabolic efficiency. Endocrine reviews,35(1),35-58. https://academic.oup.com/edrv/article/35/1/35/2354664
Zarei, M., Zaeemi, M., & Rashidlamir, A. (2018). Effects of testosterone enanthate treatment in conjunction with resistance training on thyroid hormones and lipid profile in male Wistar rats. Andrologia, 50(2), e12862. https://doi.org/10.1111/and.12862
Zhang, H. J., He, J., Pan, L. L., Ma, Z. M., Han, C. K., Chen, C. S., ... & Zhang, J. F. (2016). Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial. JAMA Internal Medicine, 176(8), 1074-1082. https://doi.org/10.1001/jamainternmed.2016.3202
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