A Tale of Two Frontal Lobes. Clinical Perspectives of Cortical Interconnectivity

Authors

  • Alina – Ioana Voinea LAS CT, Hertfordshire Partnership University NHS Foundation Trust, St. Albans, United Kingdom
  • Mirona Letitia Dobri IIIrd Year Psychiatry Resident, “Socola”Institute of Psychiatry, Iasi, Romania
  • Codrina Moraru IInd Year Psychiatry Resident, “Socola”Institute of Psychiatry, Iasi, Romania
  • Petronela Nechita MD, PhD, Senior Psychiatrist, “Socola”Institute of Psychiatry, Iasi, Romania
  • Anamaria Ciubara MD, PhD, Professor of Psychiatry, “Dunarea de Jos” University

DOI:

https://doi.org/10.18662/brain/11.3Sup1/128

Keywords:

frontal systems, neuronal interconnectivity, cortical mapping, clinical psychopathology

Abstract

Even through centuries passed, while neurosciences were mistaken only for phrenology, and neuronal mapping did not exist as a self-sustained science, structural changes of the brain were associated, at various degrees, with reoccurring activities or behavioural patterns of the patient. An extraordinary neuroplasticity was therefore described, meant to complete the cerebral network, which sustained superior cognitive functioning and played an essential role in adapting to the environment. Most of this web of electrical impulses has its nodes inside the frontal system, in such a way that no one lobe can be identical to another, structurally or when considering informational content. Cortical interconnectivity observed in frontal lobes may be a measure of physiological variety, but also an aid in understanding linked psychopathology. The first case we will focus our attention on is Phineas Gage, the railway worker who marked the history of neuroscience through his bizarre accident and unexpected outcome. Beyond the myth, this famous patient amended the understanding of the brain’s organization and revolutionized functional cerebral mapping. From here on, we will follow the evolution of neuronal connectivity studies and their implications in psychiatric pathology, as they are known today. Neuroimaging studies on obsessive compulsive disorders, cerebral lesions masked by different psychiatric phenomena, as well as correlations between certain affected tracts and symptoms of psychotic disturbances, are all scientific events which may offer new directions in clinical psychopathology and can invoke different therapeutic resources. In conclusion, to follow studies of neuronal mapping and use the understanding we already have, might be the answer to more complex case management, improving a patient’s outcome and helping us choose treatment plans more effectively. As a story unfolding from two opposing perspectives, the science behind cortical interconnectivity stands witness to different principles acting in conjunction for better results, should one only use it.

References

Bolos, A., Ciubara, A-M, & Chirita, R. (2012). Moral And Ethical Aspects Of The Relationship Between Depression And Suicide. Revista Romana De Bioetica, 10(3), 71-79.

Burlea, G., Burlea, A. M., & Milici, R. C. (2010). Prevention and intervention in speech and language therapy for the success of lexicographical acquisitions. Revista de Cercetare si Interventie Sociala, 30, 86-100. https://www.rcis.ro/images/documente/rcis30_07.pdf

Chirita, R, Sacuiu, I, Burlea, A, & Chirita, V. (2012). The role of nitric oxide inhibitors in treatment on symptom severity and cognitive deficits in schizophrenia. International Journal Of Neuropsychopharmacology,15,113-113.

Goghari, V. M. Truong, W., & Spilka, M. J. (2015). A magnetic resonance imaging family study of cortical thickness in schizophrenia. American Journal of Medical Genetics, 168, 660-668. https://doi.org/10.1002/ajmg.b.32354

Harlow, J. M. (1868). Recovery from the passage of an iron bar through the head. Publications of the Massachusetts Medical Society, 2(3). Reprinted by David Clapp & Son, 1869. 22 pages.

Haukvik, U. K., Hartberg, C. B., & Agartz, I. (2013). Schizophrenia--what does structural MRI show? Tidsskr Nor Laegeforen, 133, 850-853. https://doi.org10.4045/tidsskr.12.1084

João, R. & Filgueiras, R. (2018). Frontal Lobe: Functional Neuroanatomy of Its Circuitry and Related Disconnection Syndromes, Prefrontal Cortex, 41. In Starcevic, A., & Filipovic, B. (Eds.), Prefrontal Cortex. IntechOpen. https://doi.org/10.5772/intechopen.79571

Lim, K. O., Hedehus, M., Moseley, M., deCrespigny, A., Sullivan, E. V., Pfefferbaum A. (1999). Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Archives Of General Psychiatry, 56(4), 367–374. https://doi.org/10.1001/archpsyc.56.4.367

MacFall, J. R., Payne, M. E., Provenzale, J. E., & Krishnan, K. R. (2001). Medialorbital frontal lesions in late-onset depression. Biological Psychiatry, 49(9), 803–806. https://doi.org/10.1016/s0006-3223(00)01113-6

Mega, M. S., & Cummings, J. L. (1994). Frontal-subcortical circuits and neuropsychiatric disorders. The Journal of Neuropsychiatry and Clinical Neurosciences, 6(4), 358-370. https://doi.org/10.1176/jnp.6.4.358

Meshberger, F. L. (1990). An Interpretation of Michelangelo's Creation of Adam Based on Neuroanatomy. JAMA, 264(14), 1837–1841. https://doi.org/10.1001/jama.1990.03450140059034

Mubarik, A., & Tohid, H. (2016). Frontal lobe alterations in schizophrenia: a review. Trends Psychiatry Psychother, 38(4), 198-206. https://doi.org/10.1590/2237-6089-2015-0088

O'Driscoll, K., & Leach, J. P. (1998). "No longer Gage": an iron bar through the head. Early observations of personality change after injury to the prefrontal cortex. BMJ, 317(7174), 1673-1674. https://doi.org/10.1136/bmj.317.7174.1673a

Slifstein, M., van de Giessen, E., Van Snellenberg, J., Thompson, J. L., Narendran, R., Gil, R., Hackett, E., Girgis, R., Ojeil, N., Moore, H., D'Souza, D., Malison, R. T., Huang, Y., Lim, K., Nabulsi, N., Carson, R. E., Lieberman, J. A., & Abi-Dargham, A. (2015). Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA psychiatry, 72(4), 316–324. https://doi.org/10.1001/jamapsychiatry.2014.2414

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Published

2020-12-21

How to Cite

Voinea, A. – I. ., Dobri, M. L. ., Moraru, C. ., Nechita, P. ., & Ciubara, A. . (2020). A Tale of Two Frontal Lobes. Clinical Perspectives of Cortical Interconnectivity. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 11(3Sup1), 127-136. https://doi.org/10.18662/brain/11.3Sup1/128

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