Study on the Impact of Depression on the Quality of Life of Patients With Psoriasis


  • Roxana Cristina Oltenacu Dunarea de Jos University of Galati, Romania
  • Gabriela Stoleriu Dunarea de Jos University of Galati, Romania
  • Lucretia Anghel Dunarea de Jos University of Galati, Romania
  • Iulia Chiscop Dunarea de Jos University of Galati, Romania
  • Anamaria Ciubara Dunarea de Jos University of Galati, Romania



Psoriasis, Depression, DLQI score, Hamilton depression scale


Introduction: Psoriasis is a chronic condition with a strong impact on the daily life of patients, especially on relationship life. This paper aims to clarify the impact of depression on the quality of life of patients with moderate psoriasis. Methods: A cross-sectional study was conducted on 16 participants with psoriasis from April to May 2023. Patients with psoriasis vulgaris completed self-administered questionnaires which include demographic characteristics, Hamilton Depression Rating Scale (HAM-D) and Dermatological Life Quality Index (DLQI). Data were collected both physically, during periodic checks and online by email. Only 16 patients met the eligibility criteria for study entry. All patients included in the study had moderate psoriasis vulgaris. Exclusion criteria for participation in the study was: current use of psychotropic medications. severe comorbidities or chronic medical conditions and visual, auditory, linguistic, or cognitive impairments. Results: After completed the Hamilton Depression Rating Scale (HAM-D) half of them 8 (50%) had a score lower than 8 (minimal depression) and the other half  8 (50%) between 8-16 (mild depression). 14 (87.5%) of the participants had a DLQI score of more than 10, indicating severe impairment in their quality of life. The results obtained showed a positive correlation between Dermatological Life Quality Index (DLQI) andHamilton Depression Rating Scale (HAM-D). Conclusions: Depressive manifestations significantly influence the quality of life of psoriasis patients analyzed. A multidisciplinary approach in treating the patient with psoriasis is indispensable because it is not only necessary to manage a disease or a "case", but also to manage a patient.



Chirita, R., Sacuiu, I., Burlea, A., & Chirita, V. (2012, June). The role of nitric oxide inhibitors in treatment on symptom severity and cognitive deficits in schizophrenia. In International Journal Of Neuropsychopharmacology, 15, pp. 113-113

De Korte, J., Mombers, F. M., Bos, J. D., & Sprangers, M. A. (2004, March). Quality of life in patients with psoriasis: a systematic literature review. In Journal of Investigative Dermatology Symposium Proceedings (Vol. 9, No. 2, pp. 140-147). Elsevier

Gupta, M. A., & Gupta, A. K. (2000). Quality of life of psoriasis patients. Journal of the European Academy of Dermatology and Venereology, 14(4), 241-242

Hawro, M., Maurer, M., Weller, K., Maleszka, R., Zalewska-Janowska, A., Kaszuba, A., ... & Hawro, T. (2017). Lesions on the back of hands and female gender predispose to stigmatization in patients with psoriasis. Journal of the American Academy of Dermatology, 76(4), 648-654.

Hong, J., Koo, B., & Koo, J. (2008). The psychosocial and occupational impact of chronic skin disease. Dermatologic therapy, 21(1), 54-59

Jungo, P., Maul, J. T., Djamei, V., von Felten, S., Kolios, A. G., Czernielewsk, J., ... & Häusermann, P. (2017). Superiority in quality of life improvement of biologics over conventional systemic drugs in a Swiss real-life psoriasis registry. Dermatology, 232(6), 655-663.

Kivelevitch, D., Michel, P., & Menter, A. (2017). Quality of life instruments in psoriasis clinical trials. British Journal of Dermatology, 176(3), 563-563

Kyriakou, A., Patsatsi, A., & Sotiriadis, D. (2014). Quality of life and severity of skin and nail involvement in patients with plaque psoriasis. European Journal of Dermatology, 24(5), 623-625. 10.1684/ejd.2014.2399

Kouris, A., Christodoulou, C., Stefanaki, C., Livaditis, M., Tsatovidou, R., Kouskoukis, C., ... & Kontochristopoulos, G. (2015). Quality of life and psychosocial aspects in Greek patients with psoriasis: a cross-sectional study. Anais brasileiros de dermatologia, 90, 841-845.

Kouris, A., Platsidaki, E., Kouskoukis, C., & Christodoulou, C. (2017). Psychological parameters of psoriasis. Psychiatrike= Psychiatriki, 28(1), 54-59

Misery, L., Thomas, L., Jullien, D., Cambazard, F., Humbert, P., Dubertret, L., ... & Taieb, C. (2008). Comparative study of stress and quality of life in outpatients consulting for different dermatoses in 5 academic departments of dermatology. European Journal of Dermatology, 18(4), 412-415. 10.1684/ejd.2008.0466

Mrowietz, U., Kragballe, K., Reich, K., Spuls, P., Griffiths, C. E. M., Nast, A., ... & Yawalkar, N. (2011). Definition of treatment goals for moderate to severe psoriasis: a European consensus. Archives of dermatological research, 303, 1-10.

Naldi, L., & Gambini, D. (2007). The clinical spectrum of psoriasis. Clinics in dermatology, 25(6), 510-518

Norris, D., Photiou, L., Tacey, M., Dolianitis, C., Varigos, G., Foley, P., & Baker, C. (2017). Biologics and dermatology life quality index (DLQI) in the Australasian psoriasis population. Journal of Dermatological Treatment, 28(8), 731-736

Popazu, C., Voicu, D., Ciubară, A. B., Dorina, S. T. A. N., & Ciubară, A. (2022). The Influence of the Mental State on the Emergency Colostomized Patients Postoperative Evolution. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 13(1Sup1), 267-276

Schenker, R. A., Ciurea, M. E., Stovicek, P. O., Ciubara, A. ., Schenker, M. ., & Marinescu, I. . (2022). Depression and anxiety - Risk factors in the evolution of breast cancer in women. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 13(1Sup1), 135-158

Silistraru, I., Ciureanu, A.I., Ciubara, A., Olariu, O., (2021). Prevalence of burnout in medical students in romania during covid-19 pandemic restrictions (preliminary data). Archiv Euromedica, 11(5), 12-15, DOI: 10.35630/2199-885X/2021/11/5.3

Strober, B., Gooderham, M., de Jong, E. M., Kimball, A. B., Langley, R. G., Lakdawala, N., ... & Menter, A. (2018). Depressive symptoms, depression, and the effect of biologic therapy among patients in Psoriasis Longitudinal Assessment and Registry (PSOLAR). Journal of the American Academy of Dermatology, 78(1), 70-80.

Williams, J.B. (1988). A structured interview guide for the Hamilton Depression Rating Scale. Arch. Gen. Psychiatry, 45, 742–747.

Whoqol Group. The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41(10):1403–1409.




How to Cite

Oltenacu, R. C., Stoleriu, G., Anghel, L., Chiscop, I., & Ciubara, A. (2024). Study on the Impact of Depression on the Quality of Life of Patients With Psoriasis. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 15(1), 550-557.

Most read articles by the same author(s)

1 2 3 4 5 > >> 

Publish your work at the Scientific Publishing House LUMEN

It easy with us: publish now your work, novel, research, proceeding at Lumen Scientific Publishing House

Send your manuscript right now