The Importance of Involving a Multidisciplinary Team in the Management of a Patient Diagnosed with TB, Associating Erythema Nodosum


  • Oana Mariana Mihailov “Dunărea de Jos” University of Galati, Galați, Romania,
  • Raul Mihailov “Dunărea de Jos” University of Galati, Galați, Romania,
  • Ciprian Dinu “Dunărea de Jos” University of Galati, Galați, Romania,
  • Alexandru Bogdan Ciubara “Dunărea de Jos” University of Galati, Galați, Romania,



Tuberculosis, children, erythema nodosum, multidisciplinary team, depression


Tuberculosis (TB) is an important and topical problem at global level, so it remains a challenge for public health policies . According to the World Health Organization (WHO), in 2018, about 10 million new TB cases worldwide were estimated. Of these, 11% are children under the age of 15. In addition to these alarming data, TB is responsible for 130,000 deaths per year in children and it is estimated that there are approximately 1 million TB-cases in the global population of children, being one of the top 10 causes of death in children worldwide.  According to the WHO, there are economic, social, cultural, ethnic/racial, psychological and behavioral factors that interfere with the occurrence of diseases, and these factors are attributed to the persistence of infectious diseases such as TB in the population, even today. Numerous specialized studies strengthen the hypothesis of associating social vulnerability with TB emergence and distribution in the community. Therefore, the development of more accurate estimates of pediatric TB cases is an urgent need for public policy scheduling and resource allocation and, consequently, for reducing morbidity and mortality from TB among children.     


Ammassari A, Murri R, Pezzotti P, et al., AdICONA Study Group: Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr. 2001, 28: 445-449.

Bjorn-Mortensen, K., Ladefoged, K., Simonsen, J., Michelsen, S. W., Sørensen, H. C. F., Koch, A., ... & Soborg, B. (2016). Erythema nodosum and the risk of tuberculosis in a high incidence setting. International Journal of Circumpolar Health, 75(1), 32666

Boonchai MD, W., Suthipinittharm MD, P., & Mahaisavariya MD, P. (1998). Panniculitis in tuberculosis: a clinicopathologic study of nodular panniculitis associated with tuberculosis. International journal of dermatology, 37(5), 361-363

Cano, A. P. G., Romaneli, M. T. N., Pereira, R. M., & Tresoldi, A. T. (2017). Tuberculose em pacientes pediátricos: como tem sido feito o diagnóstico?. Revista Paulista de Pediatria, 35, 165-170.

Chen, S. A., Chen, J., Chen, L., Zhang, Q. A., Luo, X., & Zhang, W. (2013). Mycobacterium tuberculosis infection is associated with the development of erythema nodosum and nodular vasculitis. PloS one, 8(5), e62653

Chiang, C. H., Tang, P. U., Lee, G. H., Chiang, T. H., Chiang, C. H., Ma, K. S. K., & Fang, C. T. (2021). Prevalence of Nontuberculous mycobacterium infections versus Tuberculosis among autopsied HIV patients in Sub-Saharan Africa: a systematic review and meta-analysis. The American Journal of Tropical Medicine and Hygiene, 104(2), 628.

Deacon, H., & Stephney, I. (2007). HIV/AIDS, stigma and children: A literature review. Cape Town: HSRC press

Dodd, P. J., Yuen, C. M., Becerra, M. C., Revill, P., Jenkins, H. E., & Seddon, J. A. (2018). Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study. The Lancet Global Health, 6(12), e1329-e1338.

Instituto Brasileiro de Geografia e Estatística. Censo demográfico 2010: resultados gerais da amostra.

Irwin, L. G., & Johnson, J. (2005). Interviewing young children: Explicating our practices and dilemmas. Qualitative health research, 15(6), 821-831.

Jenkins, H. E., Yuen, C. M., Rodriguez, C. A., Nathavitharana, R. R., McLaughlin, M. M., Donald, P., ... & Becerra, M. C. (2017). Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. The Lancet Infectious Diseases, 17(3), 285-295

Jenkins, H. E., Tolman, A. W., Yuen, C. M., Parr, J. B., Keshavjee, S., Pérez-Vélez, C. M., ... & Cohen, T. (2014). Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. The Lancet, 383(9928), 1572-1579

Kulldorff, M., & Nagarwalla, N. (1995). Spatial disease clusters: detection and inference. Statistics in medicine, 14(8), 799-810

Lassi, Z. S., Naseem, R., Salam, R. A., Siddiqui, F., & Das, J. K. (2021). The impact of the COVID-19 pandemic on immunization campaigns and programs: a systematic review. International journal of environmental research and public health, 18(3), 988

Lupu, V.V., Ignat, A., Stoleriu, G., Ciubara, A. B., Ciubara, A., Lupu, V., Burlea, M., Stratciuc, S. (2017). Vaccination of children in Romania between civic obligation and personal choice. Revista de Cercetare si Interventie Socială, 56, 123-132

Marais, B. J., Gie, R. P., Schaaf, H. S., Hesseling, A. C., Obihara, C. C., Starke, J. J., ... & Beyers, N. (2004). The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art]. The International Journal of Tuberculosis and Lung Disease, 8(4), 392-402.

Marais, B. J. (2018). Preventing tuberculosis in household contacts crucial to protect children and contain epidemic spread. The Lancet Global Health, 6(12), e1260-e1261.

Mert, A., Bilir, M., Tabak, F., Ozaras, R., Ozturk, R., Senturk, H., ... & Aktuglu, Y. (2001). Miliary tuberculosis: clinical manifestations, diagnosis and outcome in 38 adults. Respirology, 6(3), 217-224

Moscibrodzki, P., Enane, L. A., Hoddinott, G., Brooks, M. B., Byron, V., Furin, J., ... & Chiang, S. S. (2021). The impact of tuberculosis on the well-being of adolescents and young adults. Pathogens, 10(12), 1591

Requena, L., & Yus, E. S. (2008). Erythema nodosum. Dermatologic clinics, 26(4), 425-438doi: 10.1016/j.det.2008.05.014. PMID: 18793974.

Schenker, R. A., Ciurea, M. E., Stovicek, P. O., Ciubara, A. ., Schenker, M. ., & Marinescu, I. . (2022). Depression and anxiety - risk factors in the evolution of breast cancer in women. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 13(1Sup1), 135-158

Untu, I., Chirita, R., Bulgaru-Iliescu, D., Chirila, B. D., Ciubara, A., & Burlea, S. L. (2015). Ethical implications of bio-psycho-social transformations entailed by the aging process. Revista de cercetare si interventie sociala, 48.

Vega, P., Sweetland, A., Acha, J., Castillo, H., Guerra, D., Fawzi, S., & Shin, S. (2004). Psychiatric issues in the management of patients with multidrug-resistant tuberculosis. The International Journal of Tuberculosis and Lung Disease, 8(6), 749-759.

WHO, G. (2020). Global tuberculosis report 2020. Glob. Tuberc. Rep, 2020

WHO, G. (2021). Global tuberculosis report 2021. Glob. Tuberc. Rep, 2021

Yerramsetti, S., Cohen, T., Atun, R., & Menzies, N. A. (2022). Global estimates of paediatric tuberculosis incidence in 2013–19: a mathematical modelling analysis. The Lancet Global Health, 10(2), e207-e215




How to Cite

Mihailov, O. M., Mihailov, R., Dinu, C., & Ciubara, A. B. (2024). The Importance of Involving a Multidisciplinary Team in the Management of a Patient Diagnosed with TB, Associating Erythema Nodosum. BRAIN. Broad Research in Artificial Intelligence and Neuroscience, 15(1), 193-207.

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